Title of my talk: Actin-dependent mechanisms of mammalian brain development and function. 
Actin filaments (F-actin) are a major structural component of neurons. During brain development, the coordinated assembly and disassembly of F-actin is important for neurogenesis or neuron migration and differentiation. Moreover, F-actin dynamics controls pre- and postsynaptic mechanisms and, hence, behavior. While impaired F-actin dynamics have been implicated in human brain developmental disorders or neuropsychiatric diseases, the mechanisms that control F-actin dynamics in neurons are only poorly understood. By exploiting gene targeted mice, we previously identified crucial functions for actin depolymerizing proteins of the ADF/cofilin family in synapse physiology and behavior. Our studies, together with work from several other groups, let ADF/cofilin emerge as a key regulator of synaptic F-actin dynamics. In search of mechanisms that control ADF/cofilin activity, we recently focused on cyclase-associated proteins CAP1 and CAP2, which can interact with actin, but also with ADF/cofilin-actin complexes. In my talk, I will summarize and discuss our findings on CAP1 and CAP2 in neurons and beyond.